Stopped-Flow

How Old Is Your Instrument?

Posted by Matt Pope on Aug 18, 2014 in Circular Dichroism, Laser Flash, Social, Stopped-Flow | 0 comments

Question-Mark-Box

The expected working lifetime is not generally listed among the vast array of performance parameters in a specifications datasheet accompanying any scientific instrument. Yet in a climate of shrinking budgets and ever scarcer government grants, this would appear to be as important a consideration as many of the headline grabbing specifications. The harsh reality is that a new instrument is a significant investment for most researchers and a quality instrument must be judged not just in terms of its performance on day one but measured over the lifetime of 10, 15, 20 or more years. Applied Photophysics has been...

New LED Light Source For Stopped-Flow Spectroscopy

Posted by Matt Pope on May 30, 2014 in News, Stopped-Flow | 0 comments

LEDs

New LED Light Source for Stopped-Flow I recently returned from a service trip to the US to work with our local support engineer Ernest Lugo in the Boston area. One particularly interesting visit we made was to Ralph Weissleder’s lab at Massachusetts General Hospital (MGH) to install an SX20 stopped-flow instrument equipped with our newly released LED light source.     MGH is affiliated to Harvard University and is home to a number of our stopped-flow instruments, including one at Nobel Prize winner Jack Szostak’s lab. These older instruments all feature the more traditional Xenon arc lamp and...

Publications Alert: Latest Stopped-Flow Research

Posted by James Law on May 20, 2014 in Publications Alerts, Stopped-Flow | 0 comments

thumbnail

This month’s publication alert highlights some of the latest scientific papers that have used stopped-flow spectroscopy as an important tool in their studies. The alert is published every month to provide you with an opportunity to sample some of what’s interesting in your areas of expertise, as well as in fields that may be far removed from your own, in order to offer more opportunities for learning of latest stopped-flow research methods, concepts and results. The papers are listed below with links to the journals where they have been published. Featured Article

The Manchester Institute of Biotechnology: Interview with Dr. Derren Heyes

Posted by James Law on Apr 2, 2014 in Circular Dichroism, News, Stopped-Flow | 0 comments

Leaves

Many of our instruments find use in research facilities that are established to provide support to a wider institution. The Manchester Institute of Biotechnology is a modern research centre purposefully created to address challenges in biotechnology through an interdisciplinary approach. It is the home of world-class research groups with access to cutting edge research facilities. The Biophysics Facility is one of largest of its kind, containing a wide range of cutting-edge instruments including several manufactured by APL.   In...

Publications Alert: Latest Stopped-Flow Research

Posted by James Law on Feb 26, 2014 in Publications Alerts, Stopped-Flow | 0 comments

Peroxiredoxin

This month’s publication alert spotlights some of the latest scientific papers that have used stopped-flow spectroscopy as an important tool in their studies. The alert is published every month to provide you with an opportunity to sample some of what’s interesting in your areas of expertise, as well as in fields that may be far removed from your own, in order to offer more opportunities for learning of latest stopped-flow research methods, concepts and results. The papers are listed below with links to the journals where they have been published. Featured Article

Drug/Membrane Interactions Probed by Stopped-Flow Spectroscopy

Posted by Lindsay Cole on Feb 18, 2014 in Publications Alerts, Stopped-Flow | Comments Off

membranethumbnail

Many drugs are amphiphiles; having both hydrophilic and hydrophobic parts that can interact with the lipid bilayer. This property is often necessary to allow the drug to cross the cell membrane. Because of this they can also bind into and disturb the lipid bilayer. Changes in the bilayer properties can alter membrane protein function. This alteration of membrane properties, as well as the function of membrane bound proteins, can result in many side-effects and other “off-target” drug effects. In the Olaf Anderson’s group at Weill Cornell Medical College in New York,  they have been developing an assay that can study this effect using Stopped-flow fluorescence. The...

Page 1 of 41234