The Most Productive Stopped-Flow Instrument?

Posted by Matt Pope on Feb 16, 2015 in Stopped-Flow | 0 comments


    Over the course of a year, I am fortunate to visit some of our customers’ labs around the world and learn more about the applications of our circular dichroism and stopped-flow instruments. One of the most enjoyable destinations is the beautiful city of Florence, where Dr Claudiu Supuran and his team at the University of Florence use an SX stopped-flow instrument to assay carbonic anhydrase inhibition properties of potential drug molecules for treatment of a number of diseases including cancer, glaucoma and malaria.       The technique...

An Introduction to Sequential Mixing on the SX Stopped Flow Spectrophotometer

Posted by Daryl Potter on Nov 7, 2014 in Stopped-Flow | 0 comments

SX20 3200x4800 2005 300dpi

An Introduction to Sequential Mixing on the SX Stopped Flow Spectrophotometer What is sequential mixing? All SX stopped flow users are familiar with single-mixing kinetic experiments, but not all users may be aware of their instruments ability to perform sequential  (a.k.a. double) -mixing kinetic experiments. Sequential mixing experiments allow three reactants to be mixed together in sequence; the first two reactants (A and B) are mixed and held in an aging loop for a pre-set time interval (milliseconds to tens of seconds), before being rapidly mixed with a third reactant (C) in the observation cell. This type of sequential mixing experiment makes it simple to...

How Old Is Your Instrument?

Posted by Matt Pope on Aug 18, 2014 in Circular Dichroism, Laser Flash, Social, Stopped-Flow | 0 comments


The expected working lifetime is not generally listed among the vast array of performance parameters in a specifications datasheet accompanying any scientific instrument. Yet in a climate of shrinking budgets and ever scarcer government grants, this would appear to be as important a consideration as many of the headline grabbing specifications. The harsh reality is that a new instrument is a significant investment for most researchers and a quality instrument must be judged not just in terms of its performance on day one but measured over the lifetime of 10, 15, 20 or more years. Applied Photophysics has been...

New LED Light Source For Stopped-Flow Spectroscopy

Posted by Matt Pope on May 30, 2014 in News, Stopped-Flow | 0 comments


New LED Light Source for Stopped-Flow I recently returned from a service trip to the US to work with our local support engineer Ernest Lugo in the Boston area. One particularly interesting visit we made was to Ralph Weissleder’s lab at Massachusetts General Hospital (MGH) to install an SX20 stopped-flow instrument equipped with our newly released LED light source.     MGH is affiliated to Harvard University and is home to a number of our stopped-flow instruments, including one at Nobel Prize winner Jack Szostak’s lab. These older instruments all feature the more traditional Xenon arc lamp and...

Publications Alert: Latest Stopped-Flow Research

Posted by James Law on May 20, 2014 in Publications Alerts, Stopped-Flow | 0 comments


This month’s publication alert highlights some of the latest scientific papers that have used stopped-flow spectroscopy as an important tool in their studies. The alert is published every month to provide you with an opportunity to sample some of what’s interesting in your areas of expertise, as well as in fields that may be far removed from your own, in order to offer more opportunities for learning of latest stopped-flow research methods, concepts and results. The papers are listed below with links to the journals where they have been published. Featured Article

The Manchester Institute of Biotechnology: Interview with Dr. Derren Heyes

Posted by James Law on Apr 2, 2014 in Circular Dichroism, News, Stopped-Flow | 0 comments


Many of our instruments find use in research facilities that are established to provide support to a wider institution. The Manchester Institute of Biotechnology is a modern research centre purposefully created to address challenges in biotechnology through an interdisciplinary approach. It is the home of world-class research groups with access to cutting edge research facilities. The Biophysics Facility is one of largest of its kind, containing a wide range of cutting-edge instruments including several manufactured by APL.   In...

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