Stopped-Flow

The Manchester Institute of Biotechnology: Interview with Dr. Derren Heyes

Posted by James Law on Apr 2, 2014 in Circular Dichroism, News, Stopped-Flow | 0 comments

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Many of our instruments find use in research facilities that are established to provide support to a wider institution. The Manchester Institute of Biotechnology is a modern research centre purposefully created to address challenges in biotechnology through an interdisciplinary approach. It is the home of world-class research groups with access to cutting edge research facilities. The Biophysics Facility is one of largest of its kind, containing a wide range of cutting-edge instruments including several manufactured by APL.   In...

Publications Alert: Latest Stopped-Flow Research

Posted by James Law on Feb 26, 2014 in Publications Alerts, Stopped-Flow | 0 comments

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This month’s publication alert spotlights some of the latest scientific papers that have used stopped-flow spectroscopy as an important tool in their studies. The alert is published every month to provide you with an opportunity to sample some of what’s interesting in your areas of expertise, as well as in fields that may be far removed from your own, in order to offer more opportunities for learning of latest stopped-flow research methods, concepts and results. The papers are listed below with links to the journals where they have been published. Featured Article

Drug/Membrane Interactions Probed by Stopped-Flow Spectroscopy

Posted by Lindsay Cole on Feb 18, 2014 in Publications Alerts, Stopped-Flow | Comments Off

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Many drugs are amphiphiles; having both hydrophilic and hydrophobic parts that can interact with the lipid bilayer. This property is often necessary to allow the drug to cross the cell membrane. Because of this they can also bind into and disturb the lipid bilayer. Changes in the bilayer properties can alter membrane protein function. This alteration of membrane properties, as well as the function of membrane bound proteins, can result in many side-effects and other “off-target” drug effects. In the Olaf Anderson’s group at Weill Cornell Medical College in New York,  they have been developing an assay that can study this effect using Stopped-flow fluorescence. The...

6 Checks for Optimum Stopped Flow Performance

Posted by Daryl Potter on Dec 17, 2013 in Stopped-Flow, Tips | 0 comments

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Our stopped flow instruments are required to pass an extensive series of tests before we allow them to leave our production facility. They have also proven themselves to be robust and highly reliable in the field. However, when it comes to acquiring data, every scientist wants accurate and precise results and these can only be achieved by ensuring that their analytical instruments are always performing optimally. The stopped flow spectrophotometer is no exception. Here we list six easy checks which can be performed periodically to maintain confidence in the stopped flow system. 1. Wavelength Accuracy Although not something which will require daily monitoring, the...

How To Replace the Lamp in an SX Stopped Flow Spectrometer

Posted by Daryl Potter on Dec 12, 2013 in Stopped-Flow, Tips | 0 comments

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As a service engineer, I frequently hear people ask: ‘How do I replace my lamp?’  Replacing a lamp is a relatively unfamiliar procedure for many users, as it is not often called for, but with a little guidance and a couple of hexagon keys, it can easily be performed by even the occasional user.  What follows is a guide of considerations, should you be thinking about replacing your lamp. Why do I Need to Replace My Lamp? Replacing the lamp on an SX stopped-flow spectrophotometer is necessary to maintain stability, light throughput and reliability. Over time the electrodes inside an arc lamp will erode, causing deposits on the interior of the bulb which reduce light...

Publications Alert: Latest Stopped-Flow Research

Posted by James Law on Dec 4, 2013 in News, Publications Alerts, Stopped-Flow | 0 comments

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This month’s publication alert spotlights some of the latest scientific papers that have used stopped-flow spectroscopy as an important tool in their studies. The alert is published every month to provide you with an opportunity to sample some of what’s interesting in your areas of expertise as well as in fields that may be far removed from your own, in order to offer more opportunities for learning of latest stopped-flow research methods, concepts and results. The papers are listed below with links to the journals where they have been published. Featured Articles 1....

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